KMID : 0870420130170040152
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Korean Journal of Hepato-Biliary-Pancreatic Surgery 2013 Volume.17 No. 4 p.152 ~ p.156
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Clinicopathological characteristics and prognostic factors in combined hepatocellular carcinoma and cholangiocarcinoma
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Park Sang-Eun
Lee Sung-Ha Yang Jae-Do Hwang Hong-Pil Hwang Si-Eun Yu Hee-Chul Cho Baik-Hwan Moon Woo-Sung
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Abstract
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Backgrounds/Aims: Combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CC) is an uncommon subtype of primary liver cancer that has rarely been reported in detail. This study was performed in order to evaluate the clin-icopathological characteristics and prognostic factors of cHCC-CC in single center.
Methods: The clinicopathological fea¡þtures of patients diagnosed and operated with cHCC-CC at Chonbuk National Hospital between July 1998 and July 2007 were retrospectively studied by comparing them with patients with only hepatocellular carcinoma (HCC) who had undergone a hepatic resection during the same period.
Results: Ten out of 152 patients who had undergone a hepatic resection were diagnosed with cHCC-CC and thus included in this study (M : F=8 : 2, median age: 52¡¾11.1 years). According to the parameters of the 7th American Joint Committee on Cancer T staging, there were 76 (50.0%), 44 (28.9%), 9 (5.9%), 18 (11.8%) and 5 (3.3%) patients with T stages 1, 2, 3a, 3b and 4, respectively. The overall survival period was longer in the HCC only group (68¡¾40.4 months) than in the combined cHCC-CC group (23¡¾40.1 months) (p£¼0.0001). The 5-year survival rate was 10% in the cHCC-CC group and 60% in the HCC group (p£¼0.0001). The disease free survival for patients with cHCC-HCC and HCC were 16¡¾37.4 and 51¡¾44.3 months, respectively (p£¼0.0001). Univariate analysis revealed that age, gender, transarterial chemoembolization (TACE), and T stage were statistically significant in terms of patient¡¯s overall survival. However, there were no significant clinicopathological factors identified by the multivariate analysis.
Conclusions: Even after the hepatic resection in the HCC, the prognosis is poorer if the patient has cholangiocellular components compared to the usual HCC.
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KEYWORD
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Combined hepatocellular cholangiocarcinoma, Survival rate, Prognostic factors
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